CXCR7 promotes the migration of fibroblasts derived from patients with acquired laryngotracheal stenosis by NF-κB signaling
نویسندگان
چکیده
Background: Laryngotracheal stenosis (LTS) is a life-threatening disease that commonly results in airway obstruction children. Traditional treatments such as laryngotracheal reconstruction and balloon dilation all have the risk of restenosis. It great importance to spare patients morbidity LTS risks restenosis associated with these treatments. Laboratory clinical trials focused on fibrosis, crucial pathological process LTS. This study was undertaken investigate function CXC chemokine receptor-7 (CXCR7) fibroblasts derived from
منابع مشابه
Bmi-1 Promotes Glioma Angiogenesis by Activating NF-κB Signaling
Angiogenesis in glioma is associated with the poor prognosis of the disease and closely correlates with the highly invasive phenotype of glioma cells, which represents the most challenging impediment against the currently glioma treatments. Bmi-1, an onco-protein, has been implicated in the progression of various human cancers, including gliomas, whereas its role in glioma angiogenesis remains ...
متن کاملSOX4 promotes melanoma cell migration and invasion though the activation of the NF-κB signaling pathway
SOX4 has been reported to be abnormally expressed in many types of cancer, including melanoma. However, its role in cell proliferation and metastasis remains controversial. In this study, SOX4 was downregulated or overexpressed in A375, A2058 and A875 melanoma cells by siRNA or lentivirus transfection, respectively. Cell metastasis was observed by Transwell assay. In an aim to elucidate the und...
متن کاملP133: Targeting NF-Κb Signaling Pathway as Potential Therapeutic with Curcumin in Treatment of Multiple Sclerosis
Curcumin is active component of turmeric and isolated from the rhizome of turmeric, a phenolic natural product. One of inflammatory disease is multiple sclerosis, a multifocal chronic autoimmune inflammatory disease of the CNS, which is also known as a perivascular demyelinating disease. Studies have been shown that neuro-inflammation can have both harmful and beneficial effects on the neuronal...
متن کاملNF-κB signaling mediates acquired resistance after PARP inhibition
PARP inhibitors are a class of promising anti-cancer drugs, with proven activity in BRCA mutant cancers. However, as with other targeted agents, treatment with PARP inhibitors generates acquired resistance within these tumors. The mechanism of this acquired resistance is poorly understood. We established cell lines that are resistant to PARP inhibitor by continuous treatment with the drug, and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational pediatrics
سال: 2023
ISSN: ['2224-4344', '2224-4336']
DOI: https://doi.org/10.21037/tp-23-118